Mohamed Amine Bani

The paper identifies a signaling axis involving SorLA, integrin, and HER2/HER3 that regulates apicobasal polarity in mucinous colorectal adenocarcinoma and shows its therapeutic relevance.

APEX infers cancer gene expression from plasma cfChIP-seq data, outperforming existing methods and enabling subtype classification and biomarker identification.

This study uses scRNA-seq to compare treatment-naive and post-treatment colorectal cancer samples, identifying markers and cell types associated with chemoresistance and response.

The paper shows that NOX4-generated ROS repress NIS in BRAFV600E-mutated thyroid cancer cells by blocking PAX8 and NKX2.1 chromatin binding through DNA damage and epigenetic mechanisms.