Synaptic mitochondrial oxidative stress drives individual variability in age-related cognitive decline in mice
Rui Yamada, Hirotaka Nagai, Chisato Numa, Yunhui Zhu, Midori Nagai, Kohei Ota, Yusuke Kawashima, Nobuhiko Ohno, Tomoyuki Furuyashiki
This study identifies synaptic mitochondrial oxidative stress as a driver of individual variability in age-related cognitive decline in mice, showing that targeting mitochondria with MitoQ reduces cognitive decline.
bioRxiv · Jan 9, 2026 · PreprintAnimal Behavior & Cognition