Author

Yunhui Zhu

Kobe UniversityORCID 0009-0005-7809-1891Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Animal Behavior & Cognition· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Chisato NumaiD· 2 shared Hirotaka NagaiiD· 2 shared Rui Yamada· 2 shared Tomoyuki FuruyashikiiD· 2 shared Kohei Ota· 1 shared Masayuki TaniguchiiD· 1 shared Midori Nagai· 1 shared Nobuhiko OhnoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 32 mutual co-author links

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2 shared papersAnimal Behavior & Cognition

Chisato NumaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Synaptic mitochondrial oxidative stress drives individual variability in age-related cognitive decline in mice

Rui Yamada, Hirotaka Nagai, Chisato Numa, Yunhui Zhu, Midori Nagai, Kohei Ota, Yusuke Kawashima, Nobuhiko Ohno, Tomoyuki Furuyashiki

This study identifies synaptic mitochondrial oxidative stress as a driver of individual variability in age-related cognitive decline in mice, showing that targeting mitochondria with MitoQ reduces cognitive decline.

bioRxiv · Jan 9, 2026 · PreprintAnimal Behavior & Cognition

Aging Converts Microglial Repopulation into Maladaptive Reprogramming that Exacerbates Cognitive Deficits

Rui Yamada, Hirotaka Nagai, Yunhui Zhu, Chisato Numa, Masayuki Taniguchi, Tomoyuki Furuyashiki

This study shows that microglial repopulation in aged mice leads to maladaptive gene expression changes and worsens cognitive decline, unlike in young mice.

bioRxiv · Jan 9, 2026 · PreprintNeuroscience