Author

Kohei Ota

Institute of Science Tokyo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Animal Behavior & Cognition· 1 Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Hideyuki ShimizuiD· 2 shared Takumi ItoiD· 2 shared Chisato NumaiD· 1 shared Hidekazu HishinumaiD· 1 shared Hirotaka NagaiiD· 1 shared Midori Nagai· 1 shared Nobuhiko OhnoiD· 1 shared Rui Yamada· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Hideyuki ShimizuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dose-dependent modeling of combinatorial drug responses stratifies patient survival and reveals therapeutic vulnerabilities in precision oncology

Kohei Ota, Takumi Ito, Hideyuki Shimizu

XACT models dose-dependent drug responses using transcriptomic data to predict patient survival and identify therapeutic vulnerabilities in cancer.

bioRxiv · Apr 21, 2026 · PreprintCancer Biology

Synaptic mitochondrial oxidative stress drives individual variability in age-related cognitive decline in mice

Rui Yamada, Hirotaka Nagai, Chisato Numa, Yunhui Zhu, Midori Nagai, Kohei Ota, Yusuke Kawashima, Nobuhiko Ohno, Tomoyuki Furuyashiki

This study identifies synaptic mitochondrial oxidative stress as a driver of individual variability in age-related cognitive decline in mice, showing that targeting mitochondria with MitoQ reduces cognitive decline.

bioRxiv · Jan 9, 2026 · PreprintAnimal Behavior & Cognition

A Functional Atlas of the Tardigrade Resistome Reveals a Diverse Molecular Toolkit for Extremotolerance

Takumi Ito, Kohei Ota, Hidekazu Hishinuma, Hideyuki Shimizu

The paper develops AEGIS, an AI tool, to discover novel guardian proteins in tardigrades, revealing a diverse molecular toolkit for extremotolerance.

bioRxiv · Jun 10, 2025 · PreprintBioinformatics