Nobuhiko Ohno

The paper describes methods to visualize and analyze the morphology of individual oligodendrocytes in mouse white matter using genetic labeling and immunostaining techniques.

This study shows that dietary phosphorus restriction allows for the multigenerational breeding of α-Klotho-deficient rats, improving survival and reproductive outcomes.

The paper reconstructs growth cones of callosal projection neurons in the developing mouse brain and finds they have a planar, dorsoventrally oriented morphology with filopodia that precede accelerated axon growth.

This study identifies synaptic mitochondrial oxidative stress as a driver of individual variability in age-related cognitive decline in mice, showing that targeting mitochondria with MitoQ reduces cognitive decline.

This study uses a mouse model of artificial hibernation to show that specific synaptic engram structures are preserved despite widespread spine and synapse elimination, suggesting their role in long-term memory retention.

This study transplants genome-edited retinal organoids into a primate macular degeneration model, showing host bipolar cells rewire and form functional synapses with grafted photoreceptors.

This study shows that GABA signaling in the optic nerve mediates experience-dependent myelination, with binocular deprivation having less impact than monocular deprivation.

The paper shows that oligodendrocytes selectively myelinate Purkinje cell axons in the mouse cerebellar white matter, with this preference established during development.

This study shows that calcium signals regulate AMPK activity, which controls mitochondrial homeostasis and dendritic growth in developing neurons.

This paper identifies shared GABA transmission pathology in L-DOPA-induced and tardive dyskinesia models through structural and functional analysis of striatal neurons.

This study identifies structural and functional connectivity of CSF-cNs in the mouse spinal cord, showing their role in locomotion through genetic targeting and electrophysiological analysis.

The paper investigates leaky expression of 3' transgenes in bicistronic vectors and shows that 5' transgenes can drive promoter-like activity, leading to Cre-independent expression.

This study reveals that individual interfascicular oligodendrocytes selectively myelinate distant axons with consistent thicknesses and that adjacent sheaths show correlated thicknesses.