Hirotaka Nagai

This study identifies synaptic mitochondrial oxidative stress as a driver of individual variability in age-related cognitive decline in mice, showing that targeting mitochondria with MitoQ reduces cognitive decline.

This study shows that microglial repopulation in aged mice leads to maladaptive gene expression changes and worsens cognitive decline, unlike in young mice.

This study shows that left and right vagal oxytocin signaling differentially control feeding and socioemotional behaviors via hypothalamic oxytocin neurons in mice.