Cell-state-dependent responses to PLK1 inhibition reveal a non-canonical microtubule-endolysosomal vulnerability in quiescent leukemia stem cells
Qiang Liu, Milena Gojsevic, Angelica Varesi, Amit Subedi, Changjjiang Xu, Faith Au Yeung, Bailey Dinel, Nathan Mbong, Liqing Jin, Amanda Mitchell, Cassie Lim, Héléna Boutzen, Andrea Arruda, Mark D Minden, Eric R. Lechman, , Jean CY Wang
This study shows that PLK1 inhibition eradicates quiescent leukemia stem cells through a non-canonical mechanism involving microtubule and endolysosomal disruption, distinct from its canonical mitotic function.
bioRxiv · Aug 26, 2026 · PreprintCancer Biology