Héléna Boutzen

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

This study shows that PLK1 inhibition eradicates quiescent leukemia stem cells through a non-canonical mechanism involving microtubule and endolysosomal disruption, distinct from its canonical mitotic function.

This study identifies stress granules as critical for AML stem cell survival and stress adaptation, revealing their role in gene regulation and potential as therapeutic targets.

The paper identifies two distinct leukemia stem cell subtypes with unique transcriptional, epigenetic, and functional properties using a patient-derived cell model and single-cell analysis.