Author

Nathan Mbong

University Health Network

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Amanda MitchelliD· 2 shared Angelica VaresiiD· 2 shared Liqing JiniD· 2 shared Alexander J. Murison· 1 shared Alfred Thomas LookiD· 1 shared Amit SubediiD· 1 shared Andrea ArrudaiD· 1 shared Bailey Dinel· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Amanda MitchellORCID

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Author profile →

2 papers

Recent·Most cited

Cell-state-dependent responses to PLK1 inhibition reveal a non-canonical microtubule-endolysosomal vulnerability in quiescent leukemia stem cells

Qiang Liu, Milena Gojsevic, Angelica Varesi, Amit Subedi, Changjjiang Xu, Faith Au Yeung, Bailey Dinel, Nathan Mbong, Liqing Jin, Amanda Mitchell, Cassie Lim, Héléna Boutzen, Andrea Arruda, Mark D Minden, Eric R. Lechman, , Jean CY Wang

This study shows that PLK1 inhibition eradicates quiescent leukemia stem cells through a non-canonical mechanism involving microtubule and endolysosomal disruption, distinct from its canonical mitotic function.

bioRxiv · Aug 26, 2026 · PreprintCancer Biology

Distinct gene regulatory networks govern hematopoietic and leukemia stem cells

Boyang Zhang, Alexander J. Murison, Angelica Varesi, Naoya Takayama, Liqing Jin, Nathan Mbong, Erwin M. Schoof, Stephanie Zhi-Juan Xie, Amanda Mitchell, Julia Etchin, Alfred Thomas Look, Mathieu Lupien, Mark David Minden, Jean C. Y. Wang, Peter W. Zandstra, , Stanley W.K. Ng

This study identifies distinct gene regulatory networks in hematopoietic stem cells and leukemia stem cells using integrated gene expression and chromatin accessibility data from AML patients and human umbilical cord blood.

bioRxiv · Sep 28, 2024 · PreprintBioinformatics