Topoisomerase IIIb protects from tumorigenesis and immune dysregulation
Md Rasel Al Mahmud, Simone Andrea Baechler, Anjali Dhall, Sourav Saha, Hongliang Zhang, Shuling Zhang, Min-Jung Lee, Nahoko Sato, Shraddha Rastogi, Suresh Kumar, Muhammad Shamsul Alam, Liton Kumar Saha, Beverly A. Mock, Valentina M. Factor, Yves G. Pommier
This study shows that Top3b loss accelerates lymphoma development and causes immune dysregulation in mice through R-loop accumulation and immune signaling activation.
bioRxiv · Mar 13, 2025 · PreprintCancer Biology