Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networks
Qing Liu, Haodi Wu, Qing-Jun Luo, Chao Jiang, Zhana Duren, Kevin Van Bortle, Mingtao Zhao, Bingqing Zhao, Jun Liu, David P. Marciano, Brittany Lee‐McMullen, Chenchen Zhu, Anil M. Narasimha, Joshua James Gruber, Andrew M. Lipchik, , Michael P. Snyder
This study shows that tyrosine kinase inhibitors cause mitochondrial dysfunction in cardiomyocytes by altering GATA4-mediated networks, and GATA4 overexpression can rescue these effects.
bioRxiv · May 4, 2020 · PreprintSystems Biology