Eric Wei

An atlas of transcriptional dynamics in maternal blood over the course of healthy pregnancy

The paper presents a longitudinal transcriptomic atlas of maternal peripheral blood during healthy pregnancy, identifying 720 pregnancy-specific genes and nine transcriptional modules associated with immune and metabolic changes.

Outpacing E. coli: Development of Vibrio natriegens as a Next-Generation Cloning Host

The paper introduces NBx CyClone, an engineered Vibrio natriegens strain, as a faster and more efficient molecular cloning host compared to traditional E. coli strains.

Personalized transcriptome signatures in a cardiomyopathy stem cell biobank

The paper establishes a cardiomyopathy stem cell biobank and identifies transcriptomic subtypes and drug response in iPSC-derived cardiomyocytes.

Experimental tests of functional molecular regeneration via a standard framework for coordinating synthetic cell building

The paper evaluates the capacity of a cell-free system to remake life-essential functions and finds that only 19 of 23 tested components can be remade, with some functions remaining incomplete.

Minicells as a potential chassis for engineering lineage-agnostic organisms

The paper demonstrates that minicells can express engineered plasmids and support substantial peptide bond formation, suggesting potential for lineage-agnostic organism engineering.

Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networks

This study shows that tyrosine kinase inhibitors cause mitochondrial dysfunction in cardiomyocytes by altering GATA4-mediated networks, and GATA4 overexpression can rescue these effects.

Molecular Choreography of Acute Exercise

The paper characterizes the dynamic multi-omic molecular response to acute exercise and identifies biomarkers of fitness.

A Literature-Based Knowledge Graph Embedding Method for Identifying Drug Repurposing Opportunities in Rare Diseases

This paper develops a knowledge graph embedding method to identify drug repurposing opportunities for rare diseases by integrating biomedical literature and validating hypotheses through external sources.

Index Switching Causes "Spreading-Of-Signal" Among Multiplexed Samples In Illumina HiSeq 4000 DNA Sequencing

On patterned flow cells using exclusion amplification, up to 5-10% of reads are credited to the wrong sample in a pool, traced to free index primers surviving library cleanup.