David P. Marciano

The paper identifies a cell-selective loss of constitutive redox support in COPD, with reduced PGC-1 target-program output in fibroblasts.

The paper shows that 8-oxoguanine can create premature-stop transcripts in PAH genes, mimicking pathogenic variants without DNA mutation.

The paper identifies disease-associated protein states caused by 8-oxoG transcriptional miscoding, showing 5.7% of pathogenic missense variants can arise without genomic mutation.

The paper introduces APAS, a method to generate environmentally relevant micro- and nanoplastics by simulating natural aging processes, and shows its ability to produce complex particles with physicochemical properties similar to real-world MNPs.

The paper identifies POLR3G as a key determinant of Pol III transcriptional identity, showing its role in SNAR-A RNA expression and its association with cancer prognosis.

This study shows that tyrosine kinase inhibitors cause mitochondrial dysfunction in cardiomyocytes by altering GATA4-mediated networks, and GATA4 overexpression can rescue these effects.