Kévin Contrepois

The paper examines gut microbiome changes in chronic systolic heart failure patients, linking microbiome alterations to disease severity and clinical improvement.

This study shows that many premalignant colorectal polyps contain multiple genetic lineages, indicating polyclonal origins rather than single-cell expansion.

This study evaluates the interlaboratory reproducibility of the MxP(R) Quant 500 metabolomics/lipidomics kit across human and rodent blood samples, showing high consistency and reliability.

This study identifies regulatory innovations in ancient gene programs that drive diapause in the African turquoise killifish, linking chromatin changes to lipid metabolism and survival.

This study tracks microbiome changes across four body sites in 86 participants over six years, revealing site-specific stability, individualized dynamics, and altered patterns in insulin-resistant individuals.

This study identifies age-related lipidomic changes in neural stem cells using mass spectrometry and shows that lipid modifications affect NSC function and activation.

This paper introduces a statistical method to identify time intervals of temporal omics biomarkers in longitudinal studies, showing high specificity and sensitivity across simulated and real datasets.

metID automates compound annotation for LC-MS data by integrating multiple databases, improving efficiency and reproducibility.

The paper presents a multi-omic analysis of mouse neutrophils, identifying age and sex-related differences in chromatin regulation and predicting increased neutrophil elastase release in males.

The paper characterizes the dynamic multi-omic molecular response to acute exercise and identifies biomarkers of fitness.

The paper shows that plasma from exercising mice reduces brain inflammation and improves memory, with clusterin as a key anti-inflammatory factor also elevated in human exercisers.