Kevin Van Bortle

The paper uses effective conductance to infer protein-protein relationships and identifies network hubs and macromolecular interactions using a new tool called CoBRAA.

The paper creates a Pol III activity atlas across tissues and cancers, revealing context-specific expression patterns and linking them to subnuclear compartmentalization.

This study identifies ABCA1 as a cholesterol efflux protein that enhances anti-cancer functions of myeloid cells, with clinical relevance in breast tumors.

The paper identifies NuRD complex interactions with Pol III and shows NuRD regulates Pol III activity at highly expressed tRNA gene clusters, modulating tRNA pool dynamics.

The paper investigates snaR-A, a cancer-associated ncRNA, showing it interacts with splicing factors and disrupts mRNA processing, contributing to cancer progression.

The paper identifies widespread Pol III recruitment to protein-coding gene promoters, revealing novel small ncRNAs and functional implications for gene regulation and cancer.

The paper identifies POLR3G as a key determinant of Pol III transcriptional identity, showing its role in SNAR-A RNA expression and its association with cancer prognosis.

This study shows that tyrosine kinase inhibitors cause mitochondrial dysfunction in cardiomyocytes by altering GATA4-mediated networks, and GATA4 overexpression can rescue these effects.

The paper identifies multi-loop activation hubs during macrophage development using Hi-C data, showing they are enriched for AP-1 binding and driven by cell-type specific transcription factors.