Jump-starting the T cell response in established tumors
Tyler R. McCaw, Mingyong Liu, Christopher D. Scharer, Jeremy M. Boss, Tian Mi, Alexander F. Rosenberg, Mei Li, Rebecca Christian Arend, Donald J. Buchsbaum, James M. Markert, Troy D. Randall
This study shows that entinostat enhances CD8+ T cell responses in tumors but only when administered during a specific window after T cell activation, and this effect can be restored by prior oncolytic virus treatment.
bioRxiv · Jun 1, 2026 · PreprintImmunology