Cell BiologyVitaPeer-reviewed
Oxidation-Driven mtDNA B-Z Transition Activates ZBP1 to Mediate Acetaminophen Hepatotoxicity
Zhang-Hua Yang, Bo-Xin Zhang, Huan-Feng Ye…·Wei Mo
This study identifies oxidative mtDNA B-Z transitions activating ZBP1 as a key mechanism in APAP-induced liver failure and shows TH107854 can reverse this process.
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