Human Adenovirus (HAdV) mediated inhibition of the tumor suppressor p53 is controlled by SUMOylation of the viral E2A/DBP protein
Miona Stubbe, Hans Christian Stubbe, Julia Mai, Verena Plank, Samuel Hofmann, Lilian Göttig, Thomas Günther, Adam T. Grundhoff, Stefan Krebs, Peter Groitl, Julia V. Mayerle, Ronald T. Hay, Thomas Dobner, Sabrina Schreiner
This study identifies SUMOylation of HAdV E2A/DBP as a mechanism to inhibit p53 activity and apoptosis, revealing a novel pathway for viral oncogenic potential.
bioRxiv · Feb 7, 2025 · PreprintCell Biology