Author

Samuel Hofmann

University Hospital HeidelbergORCID 0000-0002-4787-8107Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:graph neural network· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Clara van KarnebeekiD· 2 shared Hans van BokhoveniD· 2 shared Nael Nadif KasriiD· 2 shared Adam T. GrundhoffiD· 1 shared Adelaide Maria Fernandes Borralho· 1 shared Alain Geille· 1 shared Albert Carbonell· 1 shared Alejandro GarantoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Clara van KarnebeekORCID

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3 papers

Recent·Most cited

NeurosciencePure Amsterdam UMCPeer-reviewedSep 1, 2026

Navigating Human Astrocyte Differentiation: Direct and Rapid one-step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network development

Imke M. E. Schuurmans, Annika Mordelt, Marta Guevara‐Ferrer…·Nael Nadif Kasri

This study presents a one-step protocol to differentiate hiPSCs into functional astrocytes, enabling co-culture with neurons to support network development.

1 citation

humanbulk RNA-seq

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BioinformaticsBioinformaticsPeer-reviewedMay 7, 2026

KG-Bench: Benchmarking Graph Neural Network Algorithms for Drug Repurposing

Siqi Wei, Christo Sasi, Jelle Piepenbrock…·Sara Pintado

KG-Bench benchmarks graph neural networks for drug repurposing using the Open Targets dataset, finding TransformerConv achieves the highest performance.

DOI 10.1093/bioinformatics/btag159

graph neural networkbenchmarking

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Cell BiologybioRxivPreprintFeb 7, 2025

Human Adenovirus (HAdV) mediated inhibition of the tumor suppressor p53 is controlled by SUMOylation of the viral E2A/DBP protein

Miona Stubbe, Hans Christian Stubbe, Julia Mai…·Sabrina Schreiner

This study identifies SUMOylation of HAdV E2A/DBP as a mechanism to inhibit p53 activity and apoptosis, revealing a novel pathway for viral oncogenic potential.

DOI 10.1101/2025.02.07.636424

humanproteomics

𝕏 PostBluesky