Author

Mira Sleiman

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Christian GallreiniD· 2 shared Janine KirsteiniD· 2 shared Agnieszka Münster‐WandowskiiD· 1 shared Ana Fernández‐VillegasiD· 1 shared Anushree Kelkar· 1 shared Britta Johanna EickholtiD· 1 shared Dimitra RantiiD· 1 shared Emilio CirriiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

Christian GallreinORCID

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Author profile →

2 papers

Recent·Most cited

Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging

Mira Sleiman, Dimitra Ranti, Sudarson Baskaran, Patricia Kreis, Saskia Muth, Christian Gallrein, Agnieszka Münster‐Wandowski, Norman Rahnis, Emilio Cirri, Britta Johanna Eickholt, Janine Kirstein

This study compares proteolytic pathway activity in neuronal compartments across aging in mice and C. elegans, revealing age-related differences in UPS and macroautophagy.

Cellular and Molecular Life Sciences · Aug 13, 2026Peer-reviewedBiochemistry

Impairment of neuronal activity occurs at the early stages of the aggregation cascade of Ab1-42 and mutant Tau

Franziska Hirsch, Nino F. Läubli, Anushree Kelkar, Mira Sleiman, Yvonne Woitzat, Christian Gallrein, Vanessa Gumz, Gurleen Kaur Kalsi, Ana Fernández‐Villegas, Gabriele S. Kaminski Schierle, Janine Kirstein

The paper shows that Aβ and mutant Tau reduce neuronal activity in young C. elegans before amyloid aggregation, with muscle-expressed Aβ affecting neurons via retrograde signaling.

Disease Models & Mechanisms · Feb 23, 2026Peer-reviewedNeuroscience