Author

Christian Gallrein

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)ORCID 0000-0002-7623-2778Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Janine KirsteiniD· 3 shared Mira Sleiman· 2 shared Agnieszka Münster‐WandowskiiD· 1 shared Alejandro Mata‐CabanaiD· 1 shared Ana Fernández‐VillegasiD· 1 shared Anita PrasiD· 1 shared Anushree Kelkar· 1 shared Bert HoubeniD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

Janine KirsteinORCID

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3 papers

Recent·Most cited

BiochemistryCellular and Molecular Life SciencesPeer-reviewedAug 13, 2026

Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging

Mira Sleiman, Dimitra Ranti, Sudarson Baskaran…·Janine Kirstein

This study compares proteolytic pathway activity in neuronal compartments across aging in mice and C. elegans, revealing age-related differences in UPS and macroautophagy.

DOI 10.1007/s00018-026-06383-y

mouseC. elegans

𝕏 PostBluesky

NeuroscienceDisease Models & MechanismsPeer-reviewedFeb 23, 2026

Impairment of neuronal activity occurs at the early stages of the aggregation cascade of Ab1-42 and mutant Tau

Franziska Hirsch, Nino F. Läubli, Anushree Kelkar…·Janine Kirstein

The paper shows that Aβ and mutant Tau reduce neuronal activity in young C. elegans before amyloid aggregation, with muscle-expressed Aβ affecting neurons via retrograde signaling.

DOI 10.1242/dmm.052295

C. elegansexperimental assay

𝕏 PostBluesky

Molecular BiologyThe EMBO JournalPeer-reviewedOct 7, 2021

The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

Anita Pras, Bert Houben, Francesco A. Aprile…·Ellen A. A. Nollen

The paper identifies MOAG-4/SERF as modifiers of amyloid formation through charge complementation, showing that charge interactions drive protein aggregation and toxicity.

25 citations

C. elegansprotein structure

𝕏 PostBluesky