Janine Kirstein

This study compares proteolytic pathway activity in neuronal compartments across aging in mice and C. elegans, revealing age-related differences in UPS and macroautophagy.

The paper shows that Aβ and mutant Tau reduce neuronal activity in young C. elegans before amyloid aggregation, with muscle-expressed Aβ affecting neurons via retrograde signaling.

This study develops two nanobodies that specifically target HSP-1, reducing its ATPase activity and protein folding capacity both in vitro and in vivo.

This study identifies NOMO as a force-bearing ER transmembrane protein essential for muscle differentiation and ER morphology under mechanical strain.

This study identifies myosin misfolding as a driver of HCM using a fluorescent reporter and C. elegans model, showing dietary restrictions can reverse defects via autophagy.

This study shows that amyloid-beta precursor protein contributes to non-pathological brain aging and learning decline in killifish and humans.

This study shows that mutant Huntingtin causes neurodevelopmental issues in human brain organoids by disrupting CHCHD2, leading to mitochondrial and metabolic problems.

The paper identifies MOAG-4/SERF as modifiers of amyloid formation through charge complementation, showing that charge interactions drive protein aggregation and toxicity.