DNMT/G9a Complex Inhibition Uncovers Epigenetic Vulnerabilities and Induces IFN-Response in Acute Myeloid Leukemia
Angelique Schönefeld, Costanza Zanetti, Eric C. Schmitt, Kevin Woods, Ashley Westerback, Sidney M. Mitsch, Frank Rühle, Simge Kelekçi, Lisa Fol, Viral Shah, Miriam Sanchez-Saez, Sophia Thevissen, Alexander Schäffer, Ulrike Regina Schmits, Daniel Sasca, , Borhane Guezguez
This study shows that inhibiting the DNMT/G9a complex targets specific epigenetic vulnerabilities in AML, inducing an IFN response and improving therapeutic outcomes.
bioRxiv · Dec 11, 2024 · PreprintCancer Biology