Catherine Wölfel

Menin-Inhibition Sensitizes Acute Myeloid Leukemia to CLEC12A-Directed CAR Cell Therapy

This paper shows menin inhibitors increase CLEC12A expression in AML, making it more responsive to CLEC12A-targeted CAR T cells, improving treatment outcomes.

T-cell receptors identified by a personalized antigen-agnostic screening approach target shared neoantigen KRAS Q61H

The paper identifies T-cell receptors targeting KRAS Q61H neoantigen in NSCLC patients using antigen-agnostic screening and demonstrates their reactivity and potential for adoptive cell therapy.

DNMT/G9a Complex Inhibition Uncovers Epigenetic Vulnerabilities and Induces IFN-Response in Acute Myeloid Leukemia

This study shows that inhibiting the DNMT/G9a complex targets specific epigenetic vulnerabilities in AML, inducing an IFN response and improving therapeutic outcomes.