Topological Demarcation By HMGB2 Is Disrupted Early Upon Senescence Entry Across Cell Types And Induces CTCF Clustering
Anne Zirkel, Miloš Nikolić, Konstantinos Sofiadis, Jan‐Philipp Mallm, Lilija Brant, Christian Becker, Janine Altmüller, Julia Franzen, Mirjam Koker, Eduardo Gade Gusmao, Ivan G. Costa, Roland Tillmann Ullrich, Wolfgang Wagner, Peter Nürnberg, Karsten Rippe, Argyris Papantonis
The paper identifies HMGB2 loss as an early event in senescence that disrupts chromatin organization by inducing CTCF clustering across multiple human cell types.
bioRxiv · Apr 14, 2017 · PreprintGenomics