Cell-state plasticity drives heterogeneity in Group 3/4 medulloblastoma
Piyush K. Joshi, Patricia Benites Goncalves da Silva, Konstantin Okonechnikov…·Lena M. Kutscher
This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.