Lena M. Kutscher

This study shows that Eomes regulates UBC differentiation and migration in mice, mirroring human UBC development, and highlights conserved molecular mechanisms in cerebellar development.

The paper integrates single-cell, spatial, and clonal data to study cranial placode development and evolution, revealing continuous transcriptional landscapes and shared progenitors between placodes.

The paper investigates sex bias in medulloblastoma by analyzing multi-omics data and mouse models, finding that testosterone drives male predominance in this tumor.

This paper creates a multi-omics atlas of human hindbrain development, revealing cellular diversity, regulatory programs, and disease relevance.

This study identifies conserved and diverged gene regulatory networks in mammalian cerebellum development using single-nucleus gene expression and chromatin accessibility data from six species.

The paper shows that CED-3 caspase in C. elegans promotes non-apoptotic linker cell dismantling but not death onset, and reveals similar mechanisms in mouse cells.

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

The paper shows BRCA1 correlates with proliferation in human neural progenitor cells and medulloblastoma, particularly in Group 3 and 4 tumors, and is linked to worse prognosis.

This study shows that loss of Elp1 in cerebellar granule cell progenitors causes ataxia and cerebellar defects in mice, suggesting a role for ELP1 in FD pathogenesis.

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

This study maps the regulatory landscape of mouse cerebellum development using snATAC-seq, identifying cis-regulatory elements and their spatiotemporal dynamics.