Piyush K. Joshi

This paper creates a multi-omics atlas of human hindbrain development, revealing cellular diversity, regulatory programs, and disease relevance.

This study identifies conserved and diverged gene regulatory networks in mammalian cerebellum development using single-nucleus gene expression and chromatin accessibility data from six species.

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

This study shows that loss of Elp1 in cerebellar granule cell progenitors causes ataxia and cerebellar defects in mice, suggesting a role for ELP1 in FD pathogenesis.

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

This study maps the regulatory landscape of mouse cerebellum development using snATAC-seq, identifying cis-regulatory elements and their spatiotemporal dynamics.

The paper identifies CDX4 as a dual-function regulator in the spinal cord that controls the sequential loss of cell potency and acquisition of differentiation states during neural progenitor maturation.