Konstantin Okonechnikov

The paper investigates sex bias in medulloblastoma by analyzing multi-omics data and mouse models, finding that testosterone drives male predominance in this tumor.

This paper creates a multi-omics atlas of human hindbrain development, revealing cellular diversity, regulatory programs, and disease relevance.

This study identifies conserved and diverged gene regulatory networks in mammalian cerebellum development using single-nucleus gene expression and chromatin accessibility data from six species.

This study compares four spatial transcriptomics technologies for analyzing medulloblastoma cryosections, highlighting their strengths and providing guidance for method selection.

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

This study maps the regulatory landscape of mouse cerebellum development using snATAC-seq, identifying cis-regulatory elements and their spatiotemporal dynamics.

This study integrates phospho-proteogenomic and single-cell transcriptomic data to subtype meningiomas and identify subtype-specific immune infiltration patterns.