Quantitative and sensitive neuroblastoma minimal residual disease detection using extrachromosomal DNA (ecDNA) breakpoints
Annabell Szymansky, Falk Hertwig, Annika Winkler, Rocío Chamorro González, Konstantin Helmsauer, Anna M. Schroeer, MJ Witthauer, Eliz Karaman, Marco Lodrini, Jasmin Wünschel, Nadine Wittstruck, Steffen Fuchs, Jessica Theißen, Barbara Hero, Richard P. Koche, , Johannes Hubertus Schulte
This study develops a method to detect minimal residual disease in neuroblastoma using ecDNA breakpoints, achieving high sensitivity and specificity in bone marrow samples.
bioRxiv · Sep 12, 2026 · PreprintCancer Biology