Bastiaan Spanjaard

This study develops a method to detect minimal residual disease in neuroblastoma using ecDNA breakpoints, achieving high sensitivity and specificity in bone marrow samples.

This study shows lineage history and developmental context jointly shape tumor-state architecture in MYCN-driven zebrafish neuroblastoma.

This study shows that ecDNA mis-segregation leads to micronuclei formation, reduced oncogene transcription, and improved patient survival in neuroblastoma.

The paper introduces moslin, a method that combines lineage and gene expression data across time points to predict cell fate and decision driver genes.

The paper identifies fibroblast-like cell types as key drivers of heart regeneration in zebrafish using single-cell transcriptomics and lineage tracing.

This study maps β-cell regeneration in zebrafish using single-cell transcriptomics, identifying hybrid β/δ cells as key contributors to diabetes recovery.

The paper uses spatial transcriptomics and single-cell RNA labeling to study mRNA localization and dynamics in early zebrafish embryos, revealing transport to primordial germ cells and evolutionary conservation.

The paper uses spatial transcriptomics to identify novel fertility genes in C. elegans by analyzing gene expression patterns in males and hermaphrodites.

The paper introduces a method to trace cell lineages and profile transcriptomes in thousands of single cells using CRISPR/Cas9 and scRNA-seq in zebrafish.

scartrace uses Cas9-induced genetic scars for clonal analysis in zebrafish, aiming at lineage reconstruction across many cells at once rather than the small subsets imaging covers.