The first transchromosomic rat model with human chromosome 21 shows robust Down syndrome features
Yasuhiro Kazuki, Feng Gao, Miho Yoshida Yamakawa, Masumi Hirabayashi, Kanako Kazuki, Naoyo Kajitani, Sachiko Miyagawa‐Tomita, Satoshi Abe, Makoto Sanbo, Hiromasa Hara, Hiroshi Kuniishi, Satoshi Ichisaka, Yoshio Hata, Moeka Koshima, Haruka Takayama, , Roger H. Reeves
The paper develops a transchromosomic rat model with human chromosome 21 that exhibits key Down syndrome features and provides a tool for DS research and drug development.
bioRxiv · Oct 3, 2021 · PreprintGenetics