Yasuhiro Kazuki

The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.

Hi-CRI quantifies low-frequency chromosomal events in living cells with a 0.01% detection limit, revealing pre-readout attrition in chromosomal transfer experiments.

The paper compares trans-chromosomic rodent models and finds rats show improved somatic hypermutation and class-switch recombination compared to mice.

The paper identifies multiple chromosome 21 genes that modulate Sonic hedgehog signaling, which is dysregulated in Down syndrome.

The paper develops a transchromosomic rat model with human chromosome 21 that exhibits key Down syndrome features and provides a tool for DS research and drug development.

This paper describes a new non-mosaic humanized mouse model of Down syndrome with a nearly complete copy of the long arm of human chromosome 21.