A yeast model of the ALS protein Matrin3 uncovers Hsp90 and its co-chaperone Sti1 as modifiers of misfolding and toxicity
Sonja E. Di Gregorio, Mohammad Esmaeili, Ahmed Salem, Martin L. Duennwald
The paper establishes a yeast model of Matrin3, showing it forms inclusions and is toxic, and identifies Hsp90 and Sti1 as modifiers of its misfolding and toxicity.
bioRxiv · Aug 24, 2021 · PreprintMolecular Biology