Ahmed Salem

Enhanced Wound Healing and Anti-Inflammatory Effects of Vitamin C-Loaded Hyaluronic Acid/Collagen Scaffolds in Preclinical Rat Models

This study evaluates a vitamin C-loaded hyaluronic acid/collagen scaffold for enhanced wound healing in rat models, showing improved fibroblast activity and reduced inflammation.

Transcriptomic Dichotomy in Melanoma: Proliferative Cell Cycle Shield vs. Autoimmune-like Chromatin Activation in Anti-PD-1 Response

This study identifies two transcriptomic profiles in melanoma patients responding or not to anti-PD-1 therapy, linking resistance to a cell cycle shield and response to autoimmune-like chromatin activation.

High-integrity nanoemulsions formulation of resiquimod (R848) enhances stability and delivery for triple negative breast cancer immunotherapy

This paper develops a nanoemulsions formulation of resiquimod to improve its stability and delivery for TNBC immunotherapy, showing enhanced autophagy and immune checkpoint modulation.

Mechanical control of the splicing factor PTBP1 regulates extracellular matrix stiffness-induced cell proliferation and mechanomemory

This study identifies PTBP1 as a mechanotransducer that regulates cell proliferation and mechanomemory through mechanosensitive splicing of Numb in response to extracellular matrix stiffness.

A yeast model of the ALS protein Matrin3 uncovers Hsp90 and its co-chaperone Sti1 as modifiers of misfolding and toxicity

The paper establishes a yeast model of Matrin3, showing it forms inclusions and is toxic, and identifies Hsp90 and Sti1 as modifiers of its misfolding and toxicity.