Manu Vatish

This study identifies differentially expressed placental exomiRs in preeclampsia and links them to maternal brain dysregulation through bioinformatic analysis and proteomic integration.

This study examines sex-specific neurovascular and cognitive deficits in offspring of preeclampsia using a murine model, finding impaired vascular function and cognition, more severe in males and females respectively.

This study shows that plasma, not extracellular vesicles, disrupts the blood-brain barrier in eclampsia, and magnesium sulfate reduces this effect by decreasing vesicle uptake and altering their protein content.

This study shows that extracellular vesicles from preeclampsia and hypoxic placentae reduce claudin-5 in the blood-brain barrier, potentially via VEGF, leading to BBB disruption and neurological deficits.

This study shows hsa-miR-9-5p from preeclampsia placental EVs reduces brain endothelial cell proliferation and migration while modulating angiogenic factors.

The paper identifies 5'-tRNA fragments in preeclampsia syncytiotrophoblast vesicles that drive macrophage inflammation and endothelial dysfunction.

The paper describes the integration of a genetic risk prediction platform into the NHS newborn screening program for Type 1 Diabetes, demonstrating a model for population-based genetic research.