The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity
Adrienne E.D. Stormo, Farbod Shavarebi, Molly FitzGibbon, Elizabeth M. Earley, Hannah D. Ahrendt, Lotus Lum, Erik Verschueren, Danielle L. Swaney, Gaia Skibinski, Abinaya Ravisankar, Jeffrey van Haren, Emily J. Davis, Jeffrey R. Johnson, John Von Dollen, Carson Balen, , Annie OF Hiniker
This study identifies TRIM1 as an E3 ligase that ubiquitinates LRRK2, regulating its localization, degradation, and toxicity in Parkinson's Disease.
The Journal of Cell Biology · Jan 5, 2022Peer-reviewedMolecular Biology