Jeffrey van Haren

Single-Cell Roadmap of Early Hemato-Endothelial Development: Functions of Atf3, Zfp711 and Bcl6b

The paper investigates the roles of Atf3, Zfp711, and Bcl6b in early hemato-endothelial lineage specification using scRNA-seq and KO mESCs, finding distinct effects on mesodermal and hematopoietic lineages.

Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1

The paper identifies USP7's role in neuronal differentiation by regulating BCOR-ncPRC1.1, revealing a shared epigenetic network in neurodevelopmental disorders.

Doublecortin reinforces microtubules to promote growth cone advance in soft environments

This study shows DCX stabilizes microtubules in growth cones, enabling neuron morphogenesis in soft environments by resisting actomyosin contractile forces.

The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity

This study identifies TRIM1 as an E3 ligase that ubiquitinates LRRK2, regulating its localization, degradation, and toxicity in Parkinson's Disease.