Longitudinal study of liver disease progression in the PEX1-Gly844Asp mouse model of mild Zellweger Spectrum Disorder
Lingxiao Chen, Hong Yul Choi, Catherine Argyriou, Monica Hsieh, Erminia Di Pietro, Wei Cui, Esther Nuebel, Caroline Daneault, Matthieu Ruiz, Daniel Charpentier, David Rhainds, Joseph G. Hacia, Văn Hùng Nguyễn, Zu‐Hua Gao, Nancy Braverman
This study tracks liver disease progression in PEX1-G844D mice, identifying peroxisomal dysfunction and metabolic changes that contribute to hepatosteatosis, inflammation, fibrosis, and cancer.
bioRxiv · May 8, 2025 · PreprintPathology