Author

Joseph G. Hacia

University of Southern CaliforniaORCID 0000-0002-1481-9282Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Catherine ArgyriouiD· 2 shared Erminia Di PietroiD· 2 shared Nancy BravermaniD· 2 shared Caroline DaneaultiD· 1 shared Daniel Charpentier· 1 shared David RhaindsiD· 1 shared Devin S. McDougaldiD· 1 shared Esther NuebeliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersGenetics

Catherine ArgyriouORCID

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2 papers

Recent·Most cited

Clinically relevant AAV8-PEX1 gene therapy preserves retinal integrity and function long-term in a murine model of Zellweger spectrum disorder

Samy Omri, Erminia Di Pietro, Devin S. McDougald, Shaghayegh Zokaei, Jean Bennett, Joseph G. Hacia, Nancy Braverman, Catherine Argyriou

This study evaluates a gene therapy for Zellweger spectrum disorder, showing long-term preservation of retinal function and structure in mice.

bioRxiv · May 14, 2026 · PreprintGenetics

Longitudinal study of liver disease progression in the PEX1-Gly844Asp mouse model of mild Zellweger Spectrum Disorder

Lingxiao Chen, Hong Yul Choi, Catherine Argyriou, Monica Hsieh, Erminia Di Pietro, Wei Cui, Esther Nuebel, Caroline Daneault, Matthieu Ruiz, Daniel Charpentier, David Rhainds, Joseph G. Hacia, Văn Hùng Nguyễn, Zu‐Hua Gao, Nancy Braverman

This study tracks liver disease progression in PEX1-G844D mice, identifying peroxisomal dysfunction and metabolic changes that contribute to hepatosteatosis, inflammation, fibrosis, and cancer.

bioRxiv · May 8, 2025 · PreprintPathology