Cellular responses to proteostasis perturbations reveal non-optimal feedback in chaperone networks
Asmita Ghosh, Abhilash Gangadharan, Monika Verma, Sarada Das, Latika Matai, Devi Prasanna Dash, Debasis Dash, Koyeli Mapa, Kausik Chakraborty
The paper investigates cellular responses to proteostasis impairments in yeast, finding that transcriptional responses often fail to restore proteostasis and that over-expression of alternative machineries can partially compensate for gene deletions.
Cellular and Molecular Life Sciences · Jan 25, 2019Peer-reviewedGenetics