Koyeli Mapa

The N-terminal Segment of the Human ANKZF1 negatively regulates its internal mitochondrial targeting signal to prevent its mitochondrial localization

This study identifies the N-terminal segment of ANKZF1 as a negative regulator of its mitochondrial targeting, revealing an internal mitochondrial signal and structural changes that enable mitochondrial localization.

ANKZF1 helps to eliminate the stress-damaged mitochondria by LC3-mediated mitophagy

This study identifies ANKZF1 as a key player in PINK1-Parkin-mediated mitophagy, showing its role in eliminating stress-damaged mitochondria through LC3 interaction.

GroEL/ES Buffers Entropic Traps In Folding Pathway During Evolution Of A Model Substrate

The paper shows that GroEL/ES buffers entropic traps in protein folding pathways introduced by mutations, which are rescued by the chaperonin, while it can also edit non-native contacts but is not utilized in vivo.

Cellular responses to proteostasis perturbations reveal non-optimal feedback in chaperone networks

The paper investigates cellular responses to proteostasis impairments in yeast, finding that transcriptional responses often fail to restore proteostasis and that over-expression of alternative machineries can partially compensate for gene deletions.

Atypical domain communication and domain functions of a Hsp110 chaperone

This study investigates the atypical domain communication and function of the yeast Hsp110 chaperone Sse1 using biophysical techniques, revealing unique structural changes and substrate binding mechanisms.