Targeting the menopause transition with metformin improves breast cancer outcomes, but discontinuation has deleterious effects on metabolic health: Findings from a preclinical model of postmenopausal breast cancer.
Karen A. Corleto, Pepper S. Schedin, Anuhya S. Kotta, Jenna L. Strandmo, Samantha Foster, Nanci Lammoglia, Moumita Karmakar, Raymond James Carroll, Paul S. MacLean, Erin Danielle Giles
This study shows that metformin reduces breast cancer in rats during early postmenopause but discontinuation harms metabolic health, linking timing of treatment to cancer and metabolic outcomes.
bioRxiv · Nov 25, 2024 · PreprintCancer Biology