Raymond James Carroll

Targeting the menopause transition with metformin improves breast cancer outcomes, but discontinuation has deleterious effects on metabolic health: Findings from a preclinical model of postmenopausal breast cancer.

This study shows that metformin reduces breast cancer in rats during early postmenopause but discontinuation harms metabolic health, linking timing of treatment to cancer and metabolic outcomes.

Joint Modeling of Gene-Environment Correlations and Interactions using Polygenic Risk Scores in Case-Control Studies

This paper develops a method to jointly model gene-environment correlations and interactions using polygenic risk scores in case-control studies, showing improved performance over standard approaches in detecting breast cancer risk interactions.