A targeted bispecific TGFBR2 antagonist antibody demonstrates cell selectivity and enhanced potency on human fibroblasts
Russell B. Fletcher, Hui Chen, Yorick Post, Yiran Yang, Navrose Dhaliwal, Yongfeng Fan, Trevor Fisher, Sung‐Jin Lee, Nicholas Suen, Molly Smith, Nick Downs, Jay Ye, Jonathan Karr, S.G. Hymowitz, Mridula K. Ray, , Yang Li
The paper develops a bispecific antibody targeting TGFBR2 on human fibroblasts, showing cell selectivity and enhanced potency while avoiding systemic toxicity.
bioRxiv · Aug 19, 2026 · PreprintCell Biology