Author

Nicholas Suen

Surrozen, Inc. (United States)ORCID 0000-0002-6388-024XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Hui CheniD· 3 shared Sung‐Jin LeeiD· 3 shared Yang LiiD· 3 shared Chenggang LuiD· 2 shared Jay Ye· 2 shared Yiran YangiD· 2 shared Yorick PostiD· 2 shared Archana Dilip· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersSynthetic Biology

Hui ChenORCID

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3 papers

Recent·Most cited

A targeted bispecific TGFBR2 antagonist antibody demonstrates cell selectivity and enhanced potency on human fibroblasts

Russell B. Fletcher, Hui Chen, Yorick Post, Yiran Yang, Navrose Dhaliwal, Yongfeng Fan, Trevor Fisher, Sung‐Jin Lee, Nicholas Suen, Molly Smith, Nick Downs, Jay Ye, Jonathan Karr, S.G. Hymowitz, Mridula K. Ray, , Yang Li

The paper develops a bispecific antibody targeting TGFBR2 on human fibroblasts, showing cell selectivity and enhanced potency while avoiding systemic toxicity.

bioRxiv · Aug 19, 2026 · PreprintCell Biology

Targeted protein degradation systems to enhance Wnt signaling

Parthasarathy Sampathkumar, Heekyung Jung, Hui Chen, Zhengjian Zhang, Nicholas Suen, Yiran Yang, Zhong Xian Huang, Tom Lopez, Robert Benisch, Sung‐Jin Lee, Jay Ye, Wen‐Chen Yeh, Yang Li

The paper describes the development of new antibodies that enhance Wnt signaling through targeted protein degradation by sequestering E3 ligases.

eLife · Feb 8, 2024Peer-reviewedSynthetic Biology

BRAIDing receptors for cell specific targeting

Hui Chen, Sung‐Jin Lee, Ryan Li, Asmiti Sura, Nicholas Suen, Archana Dilip, Yan Pomogov, Meghah Vuppalapaty, Timothy T. Suen, Chenggang Lu, Yorick Post, Yang Li

The paper introduces a cell-specific targeting strategy called BRAID, validated using the WNT/{beta}-catenin system, showing it can induce signaling specifically on hepatocytes.

eLife · Sep 14, 2023Peer-reviewedSynthetic Biology