Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation
Bhaskar K. Chatterjee, Muhammad Mansoor Alam, Arghya Chakravorty, Shannon M. Lacy, William Giblin, Jason C. Rech, Charles L. Brooks, Peter Arvan, Matthias C. Truttmann
This study identifies two small molecule inhibitors of FICD that suppress both endogenous and pathologic protein AMPylation, improving proinsulin processing in β cells.
ACS Chemical Biology · Mar 4, 2025Peer-reviewedCell Biology