Author

Shannon M. Lacy

University of MichiganORCID 0000-0001-8730-0791Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Matthias C. TruttmanniD· 3 shared Nicholas D. UrbaniD· 2 shared Adam KlaissiD· 1 shared Adam S. HelmsiD· 1 shared Arghya ChakravortyiD· 1 shared Benedict AbdoniD· 1 shared Bhaskar K. ChatterjeeiD· 1 shared Charles L. BrooksiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

Matthias C. TruttmannORCID

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3 papers

Recent·Most cited

FICD deficiency protects mice from hypertrophy-induced heart failure via BiP-mediated activation of the UPRER and ER-phagy

Shannon M. Lacy, Rebecca J. Taubitz, Nicholas D. Urban, Samantha N. Turowski, Eric N. Primack, Eric D. Smith, Adam S. Helms, Daniel E. Michele, Matthias C. Truttmann

This study shows that FICD deficiency protects mice from heart failure by enhancing BiP-mediated UPRER and ER-phagy under stress.

Journal of the American Heart Association · Aug 18, 2025Peer-reviewedCell Biology

Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation

Bhaskar K. Chatterjee, Muhammad Mansoor Alam, Arghya Chakravorty, Shannon M. Lacy, William Giblin, Jason C. Rech, Charles L. Brooks, Peter Arvan, Matthias C. Truttmann

This study identifies two small molecule inhibitors of FICD that suppress both endogenous and pathologic protein AMPylation, improving proinsulin processing in β cells.

ACS Chemical Biology · Mar 4, 2025Peer-reviewedCell Biology

Functionally diversified BiP orthologs control body growth, reproduction, stress resistance, aging, and ER-Phagy in Caenorhabditis elegans.

Nicholas D. Urban, Shannon M. Lacy, Kate M. Van Pelt, Benedict Abdon, Zachary Mattiola, Adam Klaiss, Sarah Tabler, Matthias C. Truttmann

This study shows how two HSP70 chaperones in C. elegans, HSP-3 and HSP-4, have distinct and overlapping roles in ER proteostasis, affecting growth, reproduction, stress resistance, aging, and ER-Phagy.

bioRxiv · Jan 14, 2025 · PreprintPhysiology