Microglia coordinate activity-dependent protein synthesis in neurons through metabolic coupling
Drew I. Adler, Alejandro Martín‐Ávila, Evan Cheng, Mauricio Martins Oliveira, Muxian Zhang, Harrison Tudor Evans, Deliang Yuan, Richard Sam, Nathan Zhang, María Clara Sellés, Olivia Mosto, Wendy J. Liu, Amy X. Guo, Shane Antony Liddelow, Robert C. Froemke, , Eric Klann
The paper shows microglia support neuronal protein synthesis by coordinating metabolic coupling in response to increased demand from motor tasks.
bioRxiv · Oct 29, 2025 · PreprintNeuroscience