Mauricio Martins Oliveira

This study shows astrocytes regulate neuronal translation through secreted proteins, with implications for neurodegenerative diseases.

The paper shows microglia support neuronal protein synthesis by coordinating metabolic coupling in response to increased demand from motor tasks.

The paper identifies neuron-type-specific mRNA translation programs during early memory consolidation and shows they are influenced by mRNA sequence features.

The paper investigates the role of the TSC-Rheb axis in Oxytocin receptor+ cells in stress-induced anxiety, finding sex-specific behavioral and neural changes in TSC mutant mice.

The paper shows that GADD34, an Integrated Stress Response effector, is used by neurons to enhance eIF2-dependent translation in response to BDNF stimulation.

This paper introduces Opto4E-BP, an optogenetic tool that inhibits translation initiation in specific cell types and times, showing it blocks long-term memory consolidation.

The paper investigates how cell-type-specific disruptions in cortico-striatal circuits in FXS model mice lead to repetitive behaviors and identifies potential therapeutic targets.

This study shows that reducing eIF2-P in Alzheimer's mouse models improves protein synthesis, synaptic plasticity, and memory.

The paper investigates early molecular changes in the APP/PS1 mouse model of Alzheimer's disease, finding dysregulation of the de novo proteome in synaptic, lysosomal, and mitochondrial pathways before pathology develops.